Sergi Leánez Selected Research

tricarbonyldichlororuthenium (II) dimer

1/2019	The Effects of Cobalt Protoporphyrin IX and Tricarbonyldichlororuthenium (II) Dimer Treatments and Its Interaction with Nitric Oxide in the Locus Coeruleus of Mice with Peripheral Inflammation.
1/2018	Administration of CORM-2 inhibits diabetic neuropathy but does not reduce dyslipidemia in diabetic mice.
1/2018	Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain.
2/2016	The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1.
1/2016	The role of carbon monoxide on the anti-nociceptive effects and expression of cannabinoid 2 receptors during painful diabetic neuropathy in mice.
8/2014	The role of gaseous neurotransmitters in the antinociceptive effects of morphine during acute thermal pain.
3/2014	Treatment with a carbon monoxide-releasing molecule inhibits chronic inflammatory pain in mice: nitric oxide contribution.
8/2013	Effects of treatment with a carbon monoxide-releasing molecule and a heme oxygenase 1 inducer in the antinociceptive effects of morphine in different models of acute and chronic pain in mice.

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Sergi Leánez Research Topics

Disease

15	Neuralgia (Stump Neuralgia) 06/2019 - 09/2010
12	Pain (Aches) 06/2019 - 01/2009
11	Hyperalgesia 06/2019 - 01/2009
8	Inflammation (Inflammations) 01/2019 - 01/2009
7	Chronic Pain 06/2019 - 08/2013
4	Diabetic Neuropathies (Diabetic Neuropathy) 01/2018 - 01/2016
3	Hypersensitivity (Allergy) 01/2016 - 01/2011
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2018 - 01/2017
2	Hyperglycemia 10/2017 - 01/2017
2	Painful Neuropathy 10/2017 - 01/2017
2	Type 2 Diabetes Mellitus (MODY) 10/2017 - 01/2017
1	Dyslipidemias (Dyslipidemia) 01/2018
1	Obesity 10/2017
1	Body Weight (Weight, Body) 01/2017
1	Diabetes Mellitus 01/2016
1	Acute Pain 08/2014
1	Visceral Pain 08/2013

Drug/Important Bio-Agent (IBA)

12	Heme Oxygenase-1IBA 06/2019 - 01/2012
12	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 01/2009
10	Carbon MonoxideIBA 01/2019 - 01/2012
10	Morphine (MS Contin)FDA LinkGeneric 01/2018 - 01/2009
9	cobaltiprotoporphyrinIBA 01/2019 - 05/2013
8	tricarbonyldichlororuthenium (II) dimerIBA 01/2019 - 08/2013
8	D-Penicillamine (2,5)- EnkephalinIBA 01/2017 - 01/2009
7	Opioid Receptors (Opioid Receptor)IBA 01/2019 - 04/2011
7	Freund's AdjuvantIBA 01/2019 - 01/2009
6	Opioid Analgesics (Opioids)IBA 01/2019 - 10/2009
6	JHW 015IBA 01/2016 - 09/2010
5	quinone (benzoquinone)IBA 06/2019 - 01/2017
5	Analgesics (Analgesic Drugs)IBA 06/2019 - 01/2016
5	NAD (NADH)IBA 06/2019 - 01/2017
4	Mitogen-Activated Protein KinasesIBA 01/2019 - 12/2017
4	EnzymesIBA 12/2017 - 12/2010
4	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 02/2016 - 05/2013
3	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 01/2017
3	sulforaphaneIBA 01/2019 - 12/2017
3	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2017
3	CannabinoidsIBA 01/2016 - 01/2011
3	EnkephalinsIBA 10/2014 - 01/2009
3	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 04/2011 - 09/2010
3	delta Opioid Receptors (delta Opioid Receptor)IBA 09/2010 - 01/2009
2	AntioxidantsIBA 06/2019 - 10/2017
2	Antidepressive Agents (Antidepressants)IBA 06/2019 - 01/2019
2	Mitogen-Activated Protein Kinase 3IBA 01/2019 - 01/2019
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2019 - 12/2017
2	Pharmaceutical PreparationsIBA 01/2018 - 08/2014
2	Transcription Factors (Transcription Factor)IBA 01/2018 - 01/2017
2	KATP ChannelsIBA 04/2011 - 01/2011
2	Adenosine Triphosphate (ATP)IBA 04/2011 - 01/2011
1	oltiprazIBA 06/2019
1	Nuclear Proteins (Protein, Nuclear)IBA 06/2019
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2019
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2019
1	JNK Mitogen-Activated Protein KinasesIBA 01/2019
1	2',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acid (1H- benzimidazol- 2- yl)(carboxymethyl)methylamideIBA 01/2019
1	Lipoproteins (Lipoprotein)IBA 01/2018
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2018
1	Streptozocin (Streptozotocin)FDA Link 01/2018
1	HDL LipoproteinsIBA 01/2018
1	4- (alpha- (4- allyl- 2,5- dimethyl- 1- piperazinyl)- 3- methoxybenzyl)- N,N- diethylbenzamideIBA 01/2017
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	tin protoporphyrin IXIBA 10/2014
1	Neurotransmitter Agents (Neurotransmitter)IBA 08/2014
1	Nitric Oxide Synthase (NO Synthase)IBA 08/2014
1	Protein Isoforms (Isoforms)IBA 08/2013
1	AcidsIBA 08/2013
1	Formaldehyde (Formol)FDA Link 08/2013
1	SaltsIBA 04/2011
1	GuanosineIBA 04/2011
1	Guanylate Cyclase (Guanylyl Cyclase)IBA 04/2011
1	Lysine (L-Lysine)FDA Link 04/2011
1	Glyburide (Glibenclamide)FDA LinkGeneric 04/2011
1	Trifluoroacetic Acid (Trifluoroacetate)IBA 04/2011
1	nitroguanidineIBA 04/2011
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2011
1	iodopravadoline (AM 630)IBA 01/2011
1	AM 251 (AM251)IBA 01/2011
1	8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioateIBA 09/2010
1	Nitric Oxide DonorsIBA 10/2009
1	NOC 18IBA 10/2009

Therapy/Procedure

2	Ligation 08/2013 - 12/2010